The Imprinted Gene Network

We recently proposed that imprinted genes belong to a gene network that controls proliferation and differentiation. This network also includes numerous genes that control the composition of the extracellular matrix. Read more…

The role of imprinted genes during cortical development

We study in vitro corticogenesis from mouse embryonic stem cells (ESCs), a model that reproduces the hallmarks of in vivo corticogenesis and holds promise for cortical repair, as well as cortex generated in vivo. Read more…

Functional characterization of the ZAC1 transcription factor

Zac1/Plagl1 is a zinc finger transcription factor that controls proliferation and apoptosis, It is maternally imprinted, is a candidate tumor suppressor gene, and is responsible for transient neonatal diabetes mellitus (TNDM). Read more…

Statistical methods for genomic data

We develop novel methods for statistical analysis of genomic data with a special focus on RNA-seq data, e.g. methods to quantify allele-specific gene expression and identify allelic bias. Read more…