{"id":69,"date":"2016-11-18T14:00:07","date_gmt":"2016-11-18T13:00:07","guid":{"rendered":"https:\/\/journotlab.wordpress.com\/?page_id=69"},"modified":"2019-01-07T12:40:04","modified_gmt":"2019-01-07T11:40:04","slug":"research","status":"publish","type":"page","link":"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<h3><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-196\" src=\"https:\/\/journot-lab.igf.cnrs.fr\/wp-content\/uploads\/2018\/01\/marketing8.png\" alt=\"\" width=\"64\" height=\"64\" \/> The Imprinted Gene Network<br \/>\n<\/strong><\/h3>\n<p><span style=\"color: #000000;\">We recently proposed that imprinted genes belong to a gene network that controls proliferation and differentiation. This network also includes numerous genes that control the composition of the extracellular matrix.<\/span> <a href=\"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/the-imprinted-gene-network\/\">Read more&#8230;<\/a><\/p>\n<h3><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-195\" src=\"https:\/\/journot-lab.igf.cnrs.fr\/wp-content\/uploads\/2018\/01\/male172.png\" alt=\"\" width=\"56\" height=\"64\" \/> The role of imprinted genes during cortical development<\/strong><\/h3>\n<p><span style=\"color: #000000;\">We study <em>in vitro<\/em> corticogenesis from mouse embryonic stem cells (ESCs), a model that reproduces the hallmarks of <em>in vivo<\/em> corticogenesis and holds promise for cortical repair, as well as cortex generated in vivo.<\/span> <a href=\"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/in-vitro-corticogenesis\/\">Read more&#8230;<\/a><\/p>\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-202\" src=\"https:\/\/journot-lab.igf.cnrs.fr\/wp-content\/uploads\/2018\/01\/science8.png\" alt=\"\" width=\"65\" height=\"64\" \/> Functional characterization of the ZAC1 transcription factor<\/h3>\n<p><span style=\"color: #000000;\"><em>Zac1<\/em>\/<em>Plagl1<\/em> is a zinc finger transcription factor that controls proliferation and apoptosis, It is maternally imprinted, is a candidate tumor suppressor gene, and is responsible for transient neonatal diabetes mellitus (TNDM).<\/span> <a href=\"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/zac1-plagl1\/\">Read more&#8230;<\/a><\/p>\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-186\" src=\"https:\/\/journot-lab.igf.cnrs.fr\/wp-content\/uploads\/2018\/01\/cell8.png\" alt=\"\" width=\"82\" height=\"64\" \/> Statistical methods for genomic data<\/h3>\n<p><span style=\"color: #000000;\">We also develop novel methods for statistical analysis of genomic data with a special focus on RNA-seq data. We also develop methods to quantify allele-specific gene expression and identify allelic bias.<\/span> <a href=\"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/stats-for-genomics\/\">Read more&#8230;<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Imprinted Gene Network We recently proposed that imprinted genes belong to a gene network that controls proliferation and differentiation. This network also includes numerous genes that control the composition of the extracellular matrix. Read more&#8230; The role of imprinted genes during cortical development We study in vitro corticogenesis from mouse embryonic stem cells (ESCs), [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-69","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/wp-json\/wp\/v2\/pages\/69","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/wp-json\/wp\/v2\/comments?post=69"}],"version-history":[{"count":22,"href":"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/wp-json\/wp\/v2\/pages\/69\/revisions"}],"predecessor-version":[{"id":649,"href":"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/wp-json\/wp\/v2\/pages\/69\/revisions\/649"}],"wp:attachment":[{"href":"https:\/\/journot-lab.igf.cnrs.fr\/index.php\/wp-json\/wp\/v2\/media?parent=69"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}